On the Server ( windows 2012 R2) you are having the issue, make a right click on Windows tile, and select run , type | control | and press enter. From control panel click view and change it to small icons, locate “Internet Options” double click on it to go to properties.Go to advance and drill down to “Security” section uncheck | Check for publisher’s certificate revocation”” click apply and close the window. Installing RU 16 on Exchange 2010 SP3.
Run the setup after the changes. When finished you can revert the changes back.